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CS101 - Introduction to Computing

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Why wrongly incorporated nucleotide while DNA replication results in permanent mutation

Question 1: Why wrongly incorporated nucleotide while DNA replication results in permanent mutation

Answer: Suggest Edit

If DNA polymerase incorporates the wrong nucleotide into a newly synthesized DNA strand a single base pair substitution will occure. Another kind of error called strand slippage happens when DNA polymeraseadds an extra nucleotide or skips a nucleotide in the newly synthesized DNA strand, which results respectively in an insertion or deletion. Strand slippage often occures in regions of the genome with repeatitive DNA sequence.

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Question 2: Why wrongly incorporated nucleotide while DNA replication results in permanent mutation

Answer: Suggest Edit

If DNA polymerase incorporates the wrong nucleotide into a newly synthesized DNA strand a single base pair substitution will occure. Another kind of error called strand slippage happens when DNA polymeraseadds an extra nucleotide or skips a nucleotide in the newly synthesized DNA strand, which results respectively in an insertion or deletion. Strand slippage often occures in regions of the genome with repeatitive DNA sequence.
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